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Doctor’s Best 5-HTP Dietary Supplement Review

Editor's Rating:

Doctor’s Best 5-HTP is a supplement used to help maintain a long list of issues including sleep disorders, headaches, premenstrual syndrome ,depression, anxiety and attention deficit disorder. In conjunction with prescription medications it can be used to relieve the symptoms of seizures and Parkinson’s disease. Doctor’s Best 5-HTP works in the brain by increasing the chemical serotonin.

Doctor’s Best 5-HTP supports a positive disposition, comes from a natural source, and is suitable for vegetarians.


Doctor’s Best 5-HTP contains 100 mg of 5-hydroxytryptophan which is a by-product of the protein L-tryptophan.  The supplement is produced from the seeds of the African plant called Griffonia simplicifolia, which is a climbing shrub native to Western and Central Africa.

Other ingredients include modified cellulose, rice powder, and magnesium stearate.

Doctor’s Best 5-HTP is tested to ensure it does not contain “Peak X”, an impurity that is similar to tryptophan, which led to over 1500 people developing eosinophilia-myalgia syndrome or EMS and resulted in 38 deaths.


The recommended dose is one capsule taken daily two to three times on an empty stomach.

Possible Side Effects

This product is not suggested for use in pregnant or breastfeeding mothers. 15% of people with Down syndrome who received 5-HTP in the long term have suffered from seizures. 5-HTP should also not be taken prior to surgery due to possible interactions with medications administered during surgery. These may cause serotonin levels to rise. This can lead to serious side effects including heart complications, shivers, and anxiety.

5-HTP is relatively safe but there have been reports of some users who have developed eosinophilia-myalgia syndrome or EMS. This is a serious condition that involves extreme muscle tenderness and abnormalities in the blood. This has been association to an accidental contaminant ingredient but there is very little scientific evidence to confirm EMS is caused by this product.

Will This Product Produce Long-Term Results?

Research has shown that by taking 5-HTP daily it can improve the symptoms of depression and fibromyalgia.


When buying this product from, new users can receive up to 10% off their first order. 60 capsules cost $9.89 and 180 capsules for $23.09. The website also offers a discount page that details all of the offers and discounts they are currently promoting.


Vitacost does offer a guarantee on this product if it is purchased through their website. They guarantee you will love it or they will take it back.


Doctor’s Best 5-HTP is cost effective compared to other 5-HTP products available. The possible side effects do create some apprehension over the possibility of developing a serious condition or developing seizures.

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Overall Rating 99.50% 87.30% 82.10% 76.80% 72.80%
Speed of Results* Extremely Fast Good Good Average Average
Quality of Ingredients Premium Good Good Average Unknown
Customer Satisfaction Evaluation 99.40% 85.30% 80% 74% 70.30%
Safety Evaluation Safe for Use Safe for Use Safe for Use Safe for Use Safe for Use
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Reorder Rate Highest Good Average Average Average
Return Policy Risk Free Unopened Unclear Good Risk Free
Success Rate* 99.40% 86.20% 81% 74.50% 69%

*The views and opinions expressed in this page are strictly those of the Editor. Results may vary from person to person and cannot be guaranteed.

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